Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach.
Kosugi, Tomomi
Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach. [electronic resource] - Journal of medicinal chemistry Aug 2012 - 6700-15 p. digital
Publication Type: Journal Article
1520-4804
10.1021/jm300411k doi
Animals
Anti-Inflammatory Agents, Non-Steroidal--chemical synthesis
Cell Line
Crystallography, X-Ray
HSP27 Heat-Shock Proteins--metabolism
Humans
Intracellular Signaling Peptides and Proteins--antagonists & inhibitors
Lipopolysaccharides--pharmacology
Male
Mice
Mice, Inbred C57BL
Models, Molecular
Phosphorylation
Protein Conformation
Protein Serine-Threonine Kinases--antagonists & inhibitors
Pyrazoles--chemical synthesis
Pyrimidines--chemical synthesis
Shock, Septic--metabolism
Small Molecule Libraries
Stereoisomerism
Structure-Activity Relationship
Tumor Necrosis Factor-alpha--biosynthesis
Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach. [electronic resource] - Journal of medicinal chemistry Aug 2012 - 6700-15 p. digital
Publication Type: Journal Article
1520-4804
10.1021/jm300411k doi
Animals
Anti-Inflammatory Agents, Non-Steroidal--chemical synthesis
Cell Line
Crystallography, X-Ray
HSP27 Heat-Shock Proteins--metabolism
Humans
Intracellular Signaling Peptides and Proteins--antagonists & inhibitors
Lipopolysaccharides--pharmacology
Male
Mice
Mice, Inbred C57BL
Models, Molecular
Phosphorylation
Protein Conformation
Protein Serine-Threonine Kinases--antagonists & inhibitors
Pyrazoles--chemical synthesis
Pyrimidines--chemical synthesis
Shock, Septic--metabolism
Small Molecule Libraries
Stereoisomerism
Structure-Activity Relationship
Tumor Necrosis Factor-alpha--biosynthesis