Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors. (Record no. 18252208)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02271 a2200673 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250515134909.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200810s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1520-4804 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/jm800214a |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Cole, Derek C |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20081030 |
| 245 00 - TITLE STATEMENT | |
| Title | Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | Oct 2008 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 5958-63 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Crystallography, X-Ray |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Dose-Response Relationship, Drug |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drug Evaluation, Preclinical |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Female |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Indoles |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Interleukin-2 |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Isoenzymes |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice, Inbred C57BL |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice, Knockout |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Models, Molecular |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Molecular Structure |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Nitriles |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Protein Kinase C |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Protein Kinase C-theta |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Protein Kinase Inhibitors |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pyridines |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Spleen |
| General subdivision | cytology |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Stereoisomerism |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Structure-Activity Relationship |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | T-Lymphocytes |
| General subdivision | drug effects |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Asselin, Magda |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Brennan, Agnes |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Czerwinski, Robert |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ellingboe, John W |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fitz, Lori |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Greco, Rita |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Huang, Xinyi |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Joseph-McCarthy, Diane |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kelly, Michael F |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kirisits, Matthew |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lee, Julie |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Li, Yuanhong |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Morgan, Paul |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Stock, Joseph R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tsao, Désirée H H |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wissner, Allan |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yang, Xiaoke |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chaudhary, Divya |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 51 |
| -- | no. 19 |
| -- | p. 5958-63 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/jm800214a">https://doi.org/10.1021/jm800214a</a> |
| Public note | Available from publisher's website |
No items available.