Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer. (Record no. 18062215)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02175 a2200613 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250515124510.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200808s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1520-4804 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/jm800386y |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Cox, Christopher D |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20080829 |
| 245 00 - TITLE STATEMENT | |
| Title | Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | Jul 2008 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 4239-52 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | ATP Binding Cassette Transporter, Subfamily B, Member 1 |
| General subdivision | metabolism |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Antineoplastic Agents |
| General subdivision | pharmacology |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Enzyme Inhibitors |
| General subdivision | pharmacology |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Kinesins |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Neoplasms |
| General subdivision | drug therapy |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Piperidines |
| General subdivision | pharmacology |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pyrroles |
| General subdivision | pharmacology |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Taxoids |
| General subdivision | pharmacology |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Coleman, Paul J |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Breslin, Michael J |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Whitman, David B |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Garbaccio, Robert M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fraley, Mark E |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Buser, Carolyn A |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Walsh, Eileen S |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hamilton, Kelly |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Schaber, Michael D |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lobell, Robert B |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tao, Weikang |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Davide, Joseph P |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Diehl, Ronald E |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abrams, Marc T |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | South, Vicki J |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Huber, Hans E |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Torrent, Maricel |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Prueksaritanont, Thomayant |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Li, Chunze |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Slaughter, Donald E |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahan, Elizabeth |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fernandez-Metzler, Carmen |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yan, Youwei |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kuo, Lawrence C |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kohl, Nancy E |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hartman, George D |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 51 |
| -- | no. 14 |
| -- | p. 4239-52 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/jm800386y">https://doi.org/10.1021/jm800386y</a> |
| Public note | Available from publisher's website |
No items available.