Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.
Cox, Christopher D
Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer. [electronic resource] - Journal of medicinal chemistry Jul 2008 - 4239-52 p. digital
Publication Type: Journal Article
1520-4804
10.1021/jm800386y doi
ATP Binding Cassette Transporter, Subfamily B, Member 1--metabolism
Antineoplastic Agents--pharmacology
Enzyme Inhibitors--pharmacology
Humans
Kinesins--antagonists & inhibitors
Neoplasms--drug therapy
Piperidines--pharmacology
Pyrroles--pharmacology
Taxoids--pharmacology
Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer. [electronic resource] - Journal of medicinal chemistry Jul 2008 - 4239-52 p. digital
Publication Type: Journal Article
1520-4804
10.1021/jm800386y doi
ATP Binding Cassette Transporter, Subfamily B, Member 1--metabolism
Antineoplastic Agents--pharmacology
Enzyme Inhibitors--pharmacology
Humans
Kinesins--antagonists & inhibitors
Neoplasms--drug therapy
Piperidines--pharmacology
Pyrroles--pharmacology
Taxoids--pharmacology