Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor. (Record no. 17894267)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02394 a2200673 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250515114610.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200807s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1464-3405 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1016/j.bmcl.2008.03.057 |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ruel, Réjean |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20080715 |
| 245 00 - TITLE STATEMENT | |
| Title | Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Bioorganic & medicinal chemistry letters |
| Date of publication, distribution, etc. | May 2008 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 2985-9 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Angiogenesis Inhibitors |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cell Line |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cytochrome P-450 CYP3A Inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drug Design |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | ERG1 Potassium Channel |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Ether-A-Go-Go Potassium Channels |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Inhibitory Concentration 50 |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice, Inbred BALB C |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Protein-Tyrosine Kinases |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pyrroles |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Structure-Activity Relationship |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Triazines |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Vascular Endothelial Growth Factor Receptor-2 |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Xenograft Model Antitumor Assays |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Thibeault, Carl |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | L'Heureux, Alexandre |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Martel, Alain |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cai, Zhen-Wei |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wei, Donna |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Qian, Ligang |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Barrish, Joel C |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mathur, Arvind |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | D'Arienzo, Celia |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hunt, John T |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kamath, Amrita |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marathe, Punit |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhang, Yueping |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Derbin, George |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wautlet, Barri |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mortillo, Steven |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jeyaseelan, Robert |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Henley, Benjamin |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tejwani, Ravindra |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bhide, Rajeev S |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Trainor, George L |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fargnoli, Joseph |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lombardo, Louis J |
| 773 0# - HOST ITEM ENTRY | |
| Title | Bioorganic & medicinal chemistry letters |
| Related parts | vol. 18 |
| -- | no. 9 |
| -- | p. 2985-9 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1016/j.bmcl.2008.03.057">https://doi.org/10.1016/j.bmcl.2008.03.057</a> |
| Public note | Available from publisher's website |
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