Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor.

Ruel, Réjean

Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor. [electronic resource] - Bioorganic & medicinal chemistry letters May 2008 - 2985-9 p. digital

Publication Type: Journal Article

1464-3405

10.1016/j.bmcl.2008.03.057 doi


Angiogenesis Inhibitors--chemical synthesis
Animals
Cell Line
Cytochrome P-450 CYP3A Inhibitors
Drug Design
ERG1 Potassium Channel
Ether-A-Go-Go Potassium Channels--antagonists & inhibitors
Humans
Inhibitory Concentration 50
Mice
Mice, Inbred BALB C
Protein-Tyrosine Kinases--antagonists & inhibitors
Pyrroles--chemical synthesis
Structure-Activity Relationship
Triazines--chemical synthesis
Vascular Endothelial Growth Factor Receptor-2--antagonists & inhibitors
Xenograft Model Antitumor Assays