Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-beta-D-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model. (Record no. 14745922)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02273 a2200637 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250514182613.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200405s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 0022-2623 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/jm034197s |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Balasubramanian, Balu N |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20040510 |
| 245 00 - TITLE STATEMENT | |
| Title | Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-beta-D-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | Mar 2004 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1609-12 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Antineoplastic Agents |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Carbazoles |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Glucosides |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Male |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Neoplasm Transplantation |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Prostatic Neoplasms |
| General subdivision | drug therapy |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Solubility |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Structure-Activity Relationship |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Topoisomerase I Inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Water |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Xenograft Model Antitumor Assays |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | St Laurent, Denis R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Saulnier, Mark G |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Long, Byron H |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bachand, Carol |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Beaulieu, Francis |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Clarke, Wendy |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Deshpande, Milind |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eummer, Jeffrey |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fairchild, Craig R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Frennesson, David B |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kramer, Robert |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lee, Frank Y |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahler, Mikael |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Martel, Alain |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Naidu, B Narasimhulu |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rose, William C |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Russell, John |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ruediger, Edward |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Solomon, Carola |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Stoffan, Karen M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wong, Henry |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wright, John J |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zimmermann, Kurt |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Vyas, Dolatrai M |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 47 |
| -- | no. 7 |
| -- | p. 1609-12 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/jm034197s">https://doi.org/10.1021/jm034197s</a> |
| Public note | Available from publisher's website |
No items available.