Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-beta-D-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model.

Balasubramanian, Balu N

Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-beta-D-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model. [electronic resource] - Journal of medicinal chemistry Mar 2004 - 1609-12 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm034197s doi


Animals
Antineoplastic Agents--chemical synthesis
Carbazoles--chemical synthesis
Glucosides--chemical synthesis
Male
Mice
Neoplasm Transplantation
Prostatic Neoplasms--drug therapy
Solubility
Structure-Activity Relationship
Topoisomerase I Inhibitors
Water
Xenograft Model Antitumor Assays