The synthesis and biological activity of a series of 2,4-diaminopyrido[2,3-d]pyrimidine based antifolates as antineoplastic and antiarthritic agents.

Gossett, L S

The synthesis and biological activity of a series of 2,4-diaminopyrido[2,3-d]pyrimidine based antifolates as antineoplastic and antiarthritic agents. [electronic resource] - Bioorganic & medicinal chemistry letters Jan 1999 - 75-8 p. digital

Publication Type: Journal Article

0960-894X

10.1016/s0960-894x(98)00683-0 doi


Animals
Anti-Inflammatory Agents, Non-Steroidal--chemistry
Antineoplastic Agents--chemistry
Arthritis, Experimental--drug therapy
Drug Evaluation, Preclinical
Drug Screening Assays, Antitumor
Enzyme Inhibitors--chemistry
Folic Acid Antagonists--chemical synthesis
Glutamates--chemistry
Guanine--analogs & derivatives
Hydroxymethyl and Formyl Transferases--antagonists & inhibitors
Leukemia--drug therapy
Lymphoma, Non-Hodgkin--drug therapy
Mice
Pemetrexed
Peptide Synthases--metabolism
Phosphoribosylglycinamide Formyltransferase
Pyrimidines--chemistry
Rats
Structure-Activity Relationship
Tetrahydrofolates--chemistry
Thymidylate Synthase--antagonists & inhibitors