IL-2, but not IL-4 and other cytokines, induces phosphorylation of a 98-kDa protein associated with SHP-2, phosphatidylinositol 3'-kinase, and Grb2.

Gadina, M

IL-2, but not IL-4 and other cytokines, induces phosphorylation of a 98-kDa protein associated with SHP-2, phosphatidylinositol 3'-kinase, and Grb2. [electronic resource] - Journal of immunology (Baltimore, Md. : 1950) Feb 1999 - 2081-6 p. digital

Publication Type: Journal Article

0022-1767


Adaptor Proteins, Signal Transducing
Antigens, Differentiation
Cells, Cultured
Cytokines--physiology
GRB2 Adaptor Protein
Humans
Interleukin-2--physiology
Interleukin-4--physiology
Intracellular Signaling Peptides and Proteins
Janus Kinase 3
Killer Cells, Natural--enzymology
Macromolecular Substances
Membrane Glycoproteins--metabolism
Molecular Weight
Neural Cell Adhesion Molecule L1
Neural Cell Adhesion Molecules--metabolism
Phosphatidylinositol 3-Kinases--metabolism
Phosphoproteins--biosynthesis
Phosphorylation
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein Tyrosine Phosphatase, Non-Receptor Type 6
Protein Tyrosine Phosphatases--biosynthesis
Protein-Tyrosine Kinases--physiology
Proteins--metabolism
Receptors, Immunologic
SH2 Domain-Containing Protein Tyrosine Phosphatases
Signal Transduction--immunology
Substrate Specificity--immunology
T-Lymphocytes--enzymology
src Homology Domains--immunology