Autonomous megakaryocyte growth in essential thrombocythemia and idiopathic myelofibrosis is not related to a c-mpl mutation or to an autocrine stimulation by Mpl-L.

Taksin, A L

Autonomous megakaryocyte growth in essential thrombocythemia and idiopathic myelofibrosis is not related to a c-mpl mutation or to an autocrine stimulation by Mpl-L. [electronic resource] - Blood Jan 1999 - 125-39 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0006-4971


Adult
Aged
Aged, 80 and over
Antigens, CD34--analysis
Autocrine Communication--genetics
Cell Division--genetics
Cell Line
Cell-Free System
Cells, Cultured
Child
Female
Humans
Male
Megakaryocytes--pathology
Middle Aged
Mutation
Neoplasm Proteins
Primary Myelofibrosis--blood
Proto-Oncogene Proteins--genetics
Receptors, Cytokine
Receptors, Thrombopoietin
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction
Thrombocythemia, Essential--blood
Thrombopoietin--blood
Transcription Factors--metabolism
Transcription, Genetic