d,l-buthionine-(S,R)-sulfoximine potentiates in vivo the therapeutic efficacy of doxorubicin against multidrug resistance protein-expressing tumors.

Vanhoefer, U

d,l-buthionine-(S,R)-sulfoximine potentiates in vivo the therapeutic efficacy of doxorubicin against multidrug resistance protein-expressing tumors. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Dec 1996 - 1961-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

1078-0432


Animals
Antineoplastic Combined Chemotherapy Protocols--therapeutic use
Buthionine Sulfoximine--administration & dosage
Doxorubicin--administration & dosage
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Drug Synergism
Female
Fibrosarcoma--drug therapy
Genes, MDR--physiology
Glutathione--blood
Humans
Immunohistochemistry
Mice
Mice, Nude
Neoplasm Transplantation
Tumor Cells, Cultured