Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase.

Hallberg, B

Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase. [electronic resource] - Oncogene Aug 1998 - 691-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0950-9232

10.1038/sj.onc.1201980 doi


Adaptor Proteins, Signal Transducing
Adaptor Proteins, Vesicular Transport
Animals
Calcium-Calmodulin-Dependent Protein Kinases--metabolism
Enzyme Activation
Epidermal Growth Factor--pharmacology
GRB2 Adaptor Protein
Guanine Nucleotide Exchange Factors
Mutation
Nerve Growth Factors--pharmacology
PC12 Cells
Phosphatidylinositol 3-Kinases--metabolism
Phosphatidylinositols--metabolism
Protein Binding
Protein Serine-Threonine Kinases
Proteins--metabolism
Proto-Oncogene Proteins--genetics
Proto-Oncogene Proteins c-akt
Rats
Receptor Protein-Tyrosine Kinases--genetics
Receptor, trkA
Receptors, Nerve Growth Factor--genetics
Shc Signaling Adaptor Proteins
Src Homology 2 Domain-Containing, Transforming Protein 1
Tyrosine--genetics
ras Guanine Nucleotide Exchange Factors
ras Proteins--metabolism