Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-gamma) promoter and subsequent downregulation of IFN-gamma production.

Mikovits, J A

Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-gamma) promoter and subsequent downregulation of IFN-gamma production. [electronic resource] - Molecular and cellular biology Sep 1998 - 5166-77 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0270-7306

10.1128/MCB.18.9.5166 doi


CD4-Positive T-Lymphocytes--cytology
Cell Cycle
Cell Line
Cell Transformation, Viral
Clone Cells
Cytokines--biosynthesis
DNA Methylation
DNA Modification Methylases--biosynthesis
Gene Expression Regulation, Enzymologic
HIV Core Protein p24--biosynthesis
HIV-1--immunology
Humans
Interferon-gamma--biosynthesis
Polymerase Chain Reaction
Promoter Regions, Genetic
T-Lymphocytes--cytology
T-Lymphocytes, Helper-Inducer--immunology