2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity.

Klutchko, S R

2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity. [electronic resource] - Journal of medicinal chemistry Aug 1998 - 3276-92 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm9802259 doi


3T3 Cells
Animals
Antineoplastic Agents--chemical synthesis
Biotransformation
Cell Division--drug effects
Cisplatin--therapeutic use
Enzyme Inhibitors--chemical synthesis
Female
Humans
Male
Mice
Mice, Nude
Molecular Conformation
Molecular Structure
Ovarian Neoplasms--drug therapy
Platelet-Derived Growth Factor--pharmacology
Protein-Tyrosine Kinases--antagonists & inhibitors
Pyrimidinones--chemical synthesis
Rats
Receptor Protein-Tyrosine Kinases--antagonists & inhibitors
Structure-Activity Relationship
Transplantation, Heterologous
Tumor Cells, Cultured