Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist.
Tecle, H
Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist. [electronic resource] - Journal of medicinal chemistry Jul 1998 - 2524-36 p. digital
Publication Type: Journal Article
0022-2623
10.1021/jm960683m doi
3T3 Cells
Adenylyl Cyclase Inhibitors
Animals
Bridged Bicyclo Compounds, Heterocyclic--chemical synthesis
CHO Cells
Cricetinae
Drug Design
Enzyme Inhibitors--chemical synthesis
Humans
Inositol Phosphates--biosynthesis
Male
Memory--drug effects
Mice
Muscarinic Agonists--chemical synthesis
Oximes--chemical synthesis
Rats
Receptor, Muscarinic M1
Receptors, Muscarinic--drug effects
Stereoisomerism
Structure-Activity Relationship
Transfection
Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist. [electronic resource] - Journal of medicinal chemistry Jul 1998 - 2524-36 p. digital
Publication Type: Journal Article
0022-2623
10.1021/jm960683m doi
3T3 Cells
Adenylyl Cyclase Inhibitors
Animals
Bridged Bicyclo Compounds, Heterocyclic--chemical synthesis
CHO Cells
Cricetinae
Drug Design
Enzyme Inhibitors--chemical synthesis
Humans
Inositol Phosphates--biosynthesis
Male
Memory--drug effects
Mice
Muscarinic Agonists--chemical synthesis
Oximes--chemical synthesis
Rats
Receptor, Muscarinic M1
Receptors, Muscarinic--drug effects
Stereoisomerism
Structure-Activity Relationship
Transfection