Hepatic responses to inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase: a comparison of atorvastatin and simvastatin.

Bergstrom, J D

Hepatic responses to inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase: a comparison of atorvastatin and simvastatin. [electronic resource] - Biochimica et biophysica acta Jan 1998 - 213-21 p. digital

Publication Type: Comparative Study; Journal Article

0006-3002

10.1016/s0005-2760(97)00182-3 doi


Animals
Anticholesteremic Agents--pharmacology
Atorvastatin
Carcinoma, Hepatocellular
Cholesterol--biosynthesis
Enzyme Induction
Heptanoic Acids--pharmacology
Humans
Hydroxymethylglutaryl CoA Reductases--biosynthesis
Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology
Kinetics
Liver--drug effects
Liver Neoplasms
Male
Pyrroles--pharmacology
RNA, Messenger--biosynthesis
Rats
Rats, Sprague-Dawley
Simvastatin--pharmacology
Transcription, Genetic--drug effects
Tumor Cells, Cultured