Structure-activity studies of fluoroalkyl-substituted gamma-butyrolactone and gamma-thiobutyrolactone modulators of GABA(A) receptor function.

Canney, D J

Structure-activity studies of fluoroalkyl-substituted gamma-butyrolactone and gamma-thiobutyrolactone modulators of GABA(A) receptor function. [electronic resource] - Bioorganic & medicinal chemistry Jan 1998 - 43-55 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0968-0896

10.1016/s0968-0896(97)10006-2 doi


4-Butyrolactone--analogs & derivatives
Animals
Anticonvulsants--pharmacology
Binding, Competitive
Bridged Bicyclo Compounds, Heterocyclic--metabolism
Cells, Cultured
Convulsants--pharmacology
Electrophysiology
Female
Fluorine Compounds--chemical synthesis
Furans--chemistry
GABA Modulators--pharmacology
Hippocampus--drug effects
Mice
Neurons--drug effects
Picrotoxin--chemistry
Rats
Receptors, GABA-A--chemistry
Structure-Activity Relationship