Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid.

Hopper, A T

Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid. [electronic resource] - Journal of medicinal chemistry Feb 1998 - 420-7 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm970034q doi


Animals
Antioxidants--chemical synthesis
Arachidonate 5-Lipoxygenase--metabolism
Arachidonic Acid--chemistry
Cell Line, Transformed
Cell Nucleus--metabolism
Cyclooxygenase 1
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors--chemical synthesis
Drug Design
Indicators and Reagents
Isoenzymes--metabolism
Lipopolysaccharides--pharmacology
Lipoxygenase Inhibitors--chemical synthesis
Macrophages, Peritoneal--drug effects
Malondialdehyde
Membrane Proteins
Models, Molecular
Molecular Conformation
Molecular Structure
NF-kappa B--metabolism
Prostaglandin-Endoperoxide Synthases--metabolism
Rats
Structure-Activity Relationship