Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide.
Selnick, H G
Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide. [electronic resource] - Journal of medicinal chemistry Nov 1997 - 3865-8 p. digital
Publication Type: Journal Article
0022-2623
10.1021/jm970517u doi
Acetamides--chemical synthesis
Administration, Oral
Animals
Anti-Arrhythmia Agents--chemical synthesis
Benzodiazepinones--chemical synthesis
Cells, Cultured
Dogs
Electrocardiography, Ambulatory--drug effects
Guinea Pigs
Heart--drug effects
Humans
Myocardium--cytology
Potassium Channel Blockers
Potassium Channels--physiology
Xenopus
Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide. [electronic resource] - Journal of medicinal chemistry Nov 1997 - 3865-8 p. digital
Publication Type: Journal Article
0022-2623
10.1021/jm970517u doi
Acetamides--chemical synthesis
Administration, Oral
Animals
Anti-Arrhythmia Agents--chemical synthesis
Benzodiazepinones--chemical synthesis
Cells, Cultured
Dogs
Electrocardiography, Ambulatory--drug effects
Guinea Pigs
Heart--drug effects
Humans
Myocardium--cytology
Potassium Channel Blockers
Potassium Channels--physiology
Xenopus