Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases.

Santra, M

Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases. [electronic resource] - The Journal of clinical investigation Jul 1997 - 149-57 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0021-9738

10.1172/JCI119507 doi


Animals
CHO Cells
Cell Cycle Proteins
Cell Division--drug effects
Cell Line
Cricetinae
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinases--antagonists & inhibitors
Cyclins--biosynthesis
Cytomegalovirus
Decorin
Enzyme Inhibitors--metabolism
Extracellular Matrix Proteins
Genetic Vectors
HeLa Cells
Humans
Kinetics
Lung
Microtubule-Associated Proteins--biosynthesis
Proteoglycans--biosynthesis
Recombinant Proteins--biosynthesis
Skin
Transfection
Tumor Cells, Cultured
Tumor Suppressor Proteins