Topoisomerase II inhibitors induce DNA double-strand breaks at a specific site within the AML1 locus.

Stanulla, M

Topoisomerase II inhibitors induce DNA double-strand breaks at a specific site within the AML1 locus. [electronic resource] - Leukemia Apr 1997 - 490-6 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0887-6924

10.1038/sj.leu.2400632 doi


Amsacrine--pharmacology
Antineoplastic Agents--adverse effects
Base Sequence
Cell Line--drug effects
DNA Damage
DNA, Neoplasm--chemistry
Dactinomycin--pharmacology
Doxorubicin--pharmacology
Etoposide--pharmacology
Genes, abl--drug effects
Humans
Leukemia, Myeloid, Acute--chemically induced
Molecular Sequence Data
Monocytes--drug effects
Restriction Mapping
Topoisomerase II Inhibitors
Translocation, Genetic