Hepatic microsomal enzyme induction, beta-oxidation, and cell proliferation following administration of clofibrate, gemfibrozil, or bezafibrate in the CD rat.

Amacher, D E

Hepatic microsomal enzyme induction, beta-oxidation, and cell proliferation following administration of clofibrate, gemfibrozil, or bezafibrate in the CD rat. [electronic resource] - Toxicology and applied pharmacology Jan 1997 - 143-50 p. digital

Publication Type: Comparative Study; Journal Article

0041-008X

10.1006/taap.1996.8007 doi


Animals
Anticholesteremic Agents--pharmacology
Bezafibrate--pharmacology
Clofibrate--pharmacology
Cyclin-Dependent Kinases--biosynthesis
Cytochrome P-450 CYP1A1--biosynthesis
Cytochrome P-450 CYP4A
Cytochrome P-450 Enzyme System--biosynthesis
Dose-Response Relationship, Drug
Enzyme Induction--drug effects
Female
Gemfibrozil--pharmacology
Isoenzymes--biosynthesis
Liver--drug effects
Male
Microbodies--drug effects
Microsomes, Liver--drug effects
Mixed Function Oxygenases--biosynthesis
Organ Size--drug effects
Oxidation-Reduction
Palmitoyl Coenzyme A--metabolism
Proliferating Cell Nuclear Antigen--biosynthesis
Rats
Rats, Inbred Strains--genetics
Sex Characteristics