Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase.

Kim, H A

Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase. [electronic resource] - Molecular and cellular biology Feb 1997 - 862-72 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0270-7306

10.1128/MCB.17.2.862 doi


Alkyl and Aryl Transferases
Animals
Axons
Biomarkers--analysis
Blood
Cell Division
Cells, Cultured
Colforsin--pharmacology
Cyclic AMP-Dependent Protein Kinases--metabolism
Enzyme Activation
Enzyme Inhibitors--pharmacology
Glia Maturation Factor
Hyperplasia
Mice
Mice, Mutant Strains
Mutation
Myelin P0 Protein--analysis
Neoplasm Invasiveness
Neovascularization, Pathologic--physiopathology
Nerve Growth Factors--pharmacology
Nerve Tissue Proteins--pharmacology
Neurofibromatosis 1--pathology
Neurofibromin 1
Oligopeptides--pharmacology
Phenotype
Protein Prenylation
Proteins--physiology
Schwann Cells--pathology
Transferases--antagonists & inhibitors