Differences in cytochrome P450-mediated biotransformation of 1,2-dichlorobenzene by rat and man: implications for human risk assessment.

Hissink, A M

Differences in cytochrome P450-mediated biotransformation of 1,2-dichlorobenzene by rat and man: implications for human risk assessment. [electronic resource] - Chemical research in toxicology Dec 1996 - 1249-56 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

0893-228X

10.1021/tx960058k doi


Animals
Biotransformation
Chlorobenzenes--pharmacokinetics
Chromatography, High Pressure Liquid
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System--metabolism
Humans
In Vitro Techniques
Insecticides--pharmacokinetics
Isoenzymes--antagonists & inhibitors
Male
Microsomes, Liver--drug effects
Protein Binding
Rats
Rats, Inbred F344
Rats, Sprague-Dawley
Rats, Wistar
Risk Assessment
Species Specificity
Spectrophotometry, Ultraviolet