Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.

Vogt, A

Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts. [electronic resource] - Oncogene Nov 1996 - 1991-9 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.

0950-9232


Actins--drug effects
Alkyl and Aryl Transferases
Animals
Benzamides--pharmacology
Cell Cycle--drug effects
Cell Division--drug effects
Cell Transformation, Neoplastic--genetics
Cells, Cultured
Cytoskeleton--drug effects
DNA--biosynthesis
Diterpenes--metabolism
Enzyme Inhibitors--pharmacology
Farnesol--metabolism
Fibroblasts--cytology
G1 Phase--drug effects
GTP-Binding Proteins--drug effects
Genes, ras
Lovastatin--pharmacology
Methionine--analogs & derivatives
Mevalonic Acid--pharmacology
Mice
Protein Prenylation--drug effects
Protein Serine-Threonine Kinases--genetics
Proto-Oncogene Proteins--genetics
Proto-Oncogene Proteins c-raf
Resting Phase, Cell Cycle--drug effects
S Phase--drug effects
Transferases--antagonists & inhibitors
rap GTP-Binding Proteins
ras Proteins--drug effects