The fumagillin analogue TNP-470 inhibits DNA synthesis of vascular smooth muscle cells stimulated by platelet-derived growth factor and insulin-like growth factor-I. Possible involvement of cyclin-dependent kinase 2.

Koyama, H

The fumagillin analogue TNP-470 inhibits DNA synthesis of vascular smooth muscle cells stimulated by platelet-derived growth factor and insulin-like growth factor-I. Possible involvement of cyclin-dependent kinase 2. [electronic resource] - Circulation research Oct 1996 - 757-64 p. digital

Publication Type: Journal Article

0009-7330

10.1161/01.res.79.4.757 doi


Animals
Antibiotics, Antineoplastic--pharmacology
Becaplermin
CDC2-CDC28 Kinases
Cattle
Cells, Cultured
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinases--metabolism
Cyclohexanes
DNA Replication--drug effects
Drug Antagonism
Insulin-Like Growth Factor I--pharmacology
Muscle, Smooth, Vascular--metabolism
O-(Chloroacetylcarbamoyl)fumagillol
Platelet-Derived Growth Factor--pharmacology
Protein Serine-Threonine Kinases--metabolism
Proto-Oncogene Proteins c-sis
Sesquiterpenes--pharmacology
Signal Transduction--drug effects