Chronic exposure of LLC-PK1 epithelia to the phorbol ester TPA produces polyp-like foci with leaky tight junctions and altered protein kinase C-alpha expression and localization.

Mullin, J M

Chronic exposure of LLC-PK1 epithelia to the phorbol ester TPA produces polyp-like foci with leaky tight junctions and altered protein kinase C-alpha expression and localization. [electronic resource] - Experimental cell research Aug 1996 - 12-22 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0014-4827

10.1006/excr.1996.0244 doi


Animals
Carcinoma
Cell Membrane--enzymology
Cell Membrane Permeability--drug effects
Cell Transformation, Neoplastic--pathology
Clone Cells
Coloring Agents
Cytosol--enzymology
Electric Impedance
Epithelial Cells
Epithelium--enzymology
Isoenzymes--analysis
LLC-PK1 Cells--drug effects
Mannitol--metabolism
Protein Kinase C--analysis
Protein Kinase C-alpha
Ruthenium Red
Swine
Tetradecanoylphorbol Acetate--pharmacology
Tight Junctions--drug effects