Early CD34high cells can be separated into KIThigh cells in which transforming growth factor-beta (TGF-beta) downmodulates c-kit and KITlow cells in which anti-TGF-beta upmodulates c-kit.

Sansilvestri, P

Early CD34high cells can be separated into KIThigh cells in which transforming growth factor-beta (TGF-beta) downmodulates c-kit and KITlow cells in which anti-TGF-beta upmodulates c-kit. [electronic resource] - Blood Sep 1995 - 1729-35 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0006-4971


Antibodies, Monoclonal--pharmacology
Antigens, CD--analysis
Antigens, CD34
Biomarkers, Tumor--analysis
Cell Separation--methods
Erythropoietin--pharmacology
Fetal Blood--cytology
Gene Expression
Glyceraldehyde-3-Phosphate Dehydrogenases--biosynthesis
Granulocyte Colony-Stimulating Factor--pharmacology
Hematopoietic Cell Growth Factors--pharmacology
Hematopoietic Stem Cells--cytology
Humans
Infant, Newborn
Interleukin-3--pharmacology
Interleukin-6--pharmacology
Kinetics
Proto-Oncogene Proteins--analysis
Proto-Oncogene Proteins c-kit
Proto-Oncogenes
RNA, Messenger--analysis
Receptor Protein-Tyrosine Kinases--analysis
Receptor, Macrophage Colony-Stimulating Factor--biosynthesis
Receptors, Colony-Stimulating Factor--analysis
Receptors, Transferrin--biosynthesis
Recombinant Proteins--pharmacology
Transforming Growth Factor beta--immunology