Amplification of the UMP synthase gene and enzyme overproduction in pyrazofurin-resistant rat hepatoma cells. Molecular cloning of a cDNA for UMP synthase.

Kanalas, J J

Amplification of the UMP synthase gene and enzyme overproduction in pyrazofurin-resistant rat hepatoma cells. Molecular cloning of a cDNA for UMP synthase. [electronic resource] - The Journal of biological chemistry Feb 1984 - 1848-53 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

0021-9258


Amides
Animals
Antibiotics, Antineoplastic--toxicity
Base Sequence
Carboxy-Lyases--genetics
Cell Line
Cloning, Molecular
DNA--metabolism
Drug Resistance
Gene Amplification
Genes
Liver Neoplasms, Experimental--enzymology
Multienzyme Complexes--genetics
Orotate Phosphoribosyltransferase--genetics
Orotidine-5'-Phosphate Decarboxylase--genetics
Pentosyltransferases--genetics
Plasmids
Pyrazoles
RNA, Messenger--genetics
Rats
Ribonucleosides--toxicity
Ribose