Methoxsalen decreases the metabolic activation and prevents the hepatotoxicity and nephrotoxicity of chloroform in mice.

Lettéron, P

Methoxsalen decreases the metabolic activation and prevents the hepatotoxicity and nephrotoxicity of chloroform in mice. [electronic resource] - Toxicology and applied pharmacology Nov 1987 - 266-73 p. digital

Publication Type: Journal Article

0041-008X

10.1016/0041-008x(87)90107-4 doi


7-Alkoxycoumarin O-Dealkylase
Aminopyrine N-Demethylase--metabolism
Animals
Biotransformation
Chloroform--metabolism
Cytochrome P-450 Enzyme System--metabolism
Dose-Response Relationship, Drug
Kidney--drug effects
Liver--drug effects
Male
Methoxsalen--pharmacology
Mice
Mice, Inbred Strains
Microsomes--enzymology
Microsomes, Liver--enzymology
NADPH-Ferrihemoprotein Reductase--metabolism
Oxygenases--metabolism
Proteins--metabolism