SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels.

Han, Dandan

SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels. [electronic resource] - Journal of cellular physiology 11 2020 - 8839-8851 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1097-4652

10.1002/jcp.29727 doi


AMP-Activated Protein Kinases--metabolism
Autophagy--physiology
Ferroptosis--physiology
Glutathione Peroxidase--metabolism
Humans
Lipid Peroxidation--drug effects
Phospholipid Hydroperoxide Glutathione Peroxidase--metabolism
Reactive Oxygen Species--metabolism
Sirtuin 3--deficiency
TOR Serine-Threonine Kinases--metabolism