A physiological model of granulopoiesis to predict clinical drug induced neutropenia from in vitro bone marrow studies: with application to a cell cycle inhibitor.

Chen, Wenbo

A physiological model of granulopoiesis to predict clinical drug induced neutropenia from in vitro bone marrow studies: with application to a cell cycle inhibitor. [electronic resource] - Journal of pharmacokinetics and pharmacodynamics 04 2020 - 163-182 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1573-8744

10.1007/s10928-020-09680-6 doi


Algorithms
Antineoplastic Agents--pharmacology
Bone Marrow--drug effects
Cell Cycle--drug effects
Cell Movement
Filgrastim--pharmacology
Granulocyte Colony-Stimulating Factor--pharmacology
Granulocytes--drug effects
Hematopoiesis--drug effects
Humans
Leukocyte Count
Models, Biological
Neutropenia--chemically induced
Neutrophils--drug effects
Piperazines--pharmacology
Polyethylene Glycols--pharmacology
Pyridines--pharmacology
Stem Cells--drug effects