Reduction of inflammation in a chronic periodontitis model in rats by TNF-α gene silencing with a topically applied siRNA-loaded calcium phosphate paste.

Tenkumo, Taichi

Reduction of inflammation in a chronic periodontitis model in rats by TNF-α gene silencing with a topically applied siRNA-loaded calcium phosphate paste. [electronic resource] - Acta biomaterialia 03 2020 - 263-279 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1878-7568

10.1016/j.actbio.2020.01.031 doi


Alkaline Phosphatase--metabolism
Animals
Anti-Inflammatory Agents--pharmacology
Calcium Phosphates--chemistry
Cell Line
Cell Survival--drug effects
Chronic Periodontitis--diagnostic imaging
Disease Models, Animal
Gene Silencing
Gingiva--pathology
Inflammation--pathology
Male
Mice, Inbred C57BL
Monocytes--cytology
Nanoparticles--chemistry
Particle Size
RNA, Small Interfering--metabolism
Rats, Wistar
Tartrate-Resistant Acid Phosphatase--metabolism
Tumor Necrosis Factor-alpha--genetics
Wound Healing--drug effects
X-Ray Microtomography