Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents.
Yang, Gui-Xiang
Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents. [electronic resource] - European journal of medicinal chemistry Feb 2020 - 111913 p. digital
Publication Type: Journal Article
1768-3254
10.1016/j.ejmech.2019.111913 doi
Aging--drug effects
Alzheimer Disease--drug therapy
Amyloid beta-Peptides--antagonists & inhibitors
Animals
Anti-Inflammatory Agents, Non-Steroidal--chemical synthesis
Astrocytes--drug effects
Carbamates--chemical synthesis
Cell Line, Tumor
Cell Survival--drug effects
Diosgenin--chemical synthesis
Dose-Response Relationship, Drug
Drug Design
Galactose--administration & dosage
Humans
Inflammation--drug therapy
Male
Mice
Mice, Inbred ICR
Molecular Structure
Neuroprotective Agents--chemical synthesis
Oxidative Stress--drug effects
Protein Aggregates--drug effects
Structure-Activity Relationship
Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents. [electronic resource] - European journal of medicinal chemistry Feb 2020 - 111913 p. digital
Publication Type: Journal Article
1768-3254
10.1016/j.ejmech.2019.111913 doi
Aging--drug effects
Alzheimer Disease--drug therapy
Amyloid beta-Peptides--antagonists & inhibitors
Animals
Anti-Inflammatory Agents, Non-Steroidal--chemical synthesis
Astrocytes--drug effects
Carbamates--chemical synthesis
Cell Line, Tumor
Cell Survival--drug effects
Diosgenin--chemical synthesis
Dose-Response Relationship, Drug
Drug Design
Galactose--administration & dosage
Humans
Inflammation--drug therapy
Male
Mice
Mice, Inbred ICR
Molecular Structure
Neuroprotective Agents--chemical synthesis
Oxidative Stress--drug effects
Protein Aggregates--drug effects
Structure-Activity Relationship