A facile di-acid mono-amidation strategy to prepare cyclization-activating mono-carboxylate transporter 1-targeting gemcitabine prodrugs for enhanced oral delivery.

Wang, Yang

A facile di-acid mono-amidation strategy to prepare cyclization-activating mono-carboxylate transporter 1-targeting gemcitabine prodrugs for enhanced oral delivery. [electronic resource] - International journal of pharmaceutics Jan 2020 - 118718 p. digital

Publication Type: Comparative Study; Journal Article

1873-3476

10.1016/j.ijpharm.2019.118718 doi


Administration, Oral
Animals
Antimetabolites, Antineoplastic--administration & dosage
Biological Availability
Caco-2 Cells
Cyclization
Deoxycytidine--administration & dosage
Drug Delivery Systems
Humans
Hydrogen-Ion Concentration
Intestinal Absorption
Monocarboxylic Acid Transporters--metabolism
Prodrugs
Rats
Rats, Wistar
Symporters--metabolism
Gemcitabine