Inactivation of the AMPK-GATA3-ECHS1 Pathway Induces Fatty Acid Synthesis That Promotes Clear Cell Renal Cell Carcinoma Growth.

Qu, Yuan-Yuan

Inactivation of the AMPK-GATA3-ECHS1 Pathway Induces Fatty Acid Synthesis That Promotes Clear Cell Renal Cell Carcinoma Growth. [electronic resource] - Cancer research 01 2020 - 319-333 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1538-7445

10.1158/0008-5472.CAN-19-1023 doi


AMP-Activated Protein Kinases--metabolism
Adult
Aged
Aged, 80 and over
Amino Acids, Branched-Chain--analysis
Animals
Carcinogenesis--genetics
Carcinoma, Renal Cell--genetics
Cell Line, Tumor
Cell Movement--genetics
Cell Proliferation
Down-Regulation
Enoyl-CoA Hydratase--metabolism
Fatty Acids--analysis
Female
GATA3 Transcription Factor--metabolism
Gene Expression Regulation, Neoplastic
HEK293 Cells
Humans
Kidney--pathology
Kidney Neoplasms--genetics
Lipogenesis--genetics
Male
Mechanistic Target of Rapamycin Complex 1--metabolism
Mice, Knockout
Middle Aged
Nephrectomy
Prognosis
Progression-Free Survival
Signal Transduction--genetics
Young Adult