Synthesis and opioid antagonist potencies of naltrexamine bivalent ligands with conformationally restricted spacers.

Portoghese, P S

Synthesis and opioid antagonist potencies of naltrexamine bivalent ligands with conformationally restricted spacers. [electronic resource] - Journal of medicinal chemistry Sep 1986 - 1650-3 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0022-2623

10.1021/jm00159a014 doi


Animals
Biological Assay
Chemical Phenomena
Chemistry
Cyclazocine--analogs & derivatives
Endorphins--antagonists & inhibitors
Ethylketocyclazocine
Guinea Pigs
Ileum--physiology
Molecular Conformation
Morphine--pharmacology
Muscle Contraction--drug effects
Naltrexone--analogs & derivatives
Receptors, Opioid--drug effects
Receptors, Opioid, kappa
Receptors, Opioid, mu
Structure-Activity Relationship