Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice.
Cottage, Christopher T
Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice. [electronic resource] - Communications biology 2019 - 307 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2399-3642
10.1038/s42003-019-0532-1 doi
Alveolar Epithelial Cells--metabolism
Animals
Cell Proliferation
Cellular Senescence
Cyclin-Dependent Kinase Inhibitor p16--genetics
Cytokines--metabolism
Emphysema--etiology
Insulin-Like Growth Factor I--genetics
Lung--metabolism
Mice, Inbred C57BL
Models, Biological
Promoter Regions, Genetic--genetics
Proto-Oncogene Proteins c-akt--genetics
Pulmonary Disease, Chronic Obstructive--metabolism
RNA, Messenger--genetics
Signal Transduction
Smoking--adverse effects
Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice. [electronic resource] - Communications biology 2019 - 307 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2399-3642
10.1038/s42003-019-0532-1 doi
Alveolar Epithelial Cells--metabolism
Animals
Cell Proliferation
Cellular Senescence
Cyclin-Dependent Kinase Inhibitor p16--genetics
Cytokines--metabolism
Emphysema--etiology
Insulin-Like Growth Factor I--genetics
Lung--metabolism
Mice, Inbred C57BL
Models, Biological
Promoter Regions, Genetic--genetics
Proto-Oncogene Proteins c-akt--genetics
Pulmonary Disease, Chronic Obstructive--metabolism
RNA, Messenger--genetics
Signal Transduction
Smoking--adverse effects