Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells.

Willbold, Ramona

Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells. [electronic resource] - Cell death & disease 08 2019 - 601 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2041-4889

10.1038/s41419-019-1830-8 doi


Animals
Autophagy--genetics
Carcinogenesis--genetics
Cinnamates--pharmacology
Endoplasmic Reticulum Stress--drug effects
Endoplasmic Reticulum-Associated Degradation--genetics
Gene Expression Regulation, Neoplastic--drug effects
Heterografts
Humans
Macrolides--pharmacology
Male
Mice
Microtubule-Associated Proteins--genetics
Neoplastic Stem Cells--metabolism
PC-3 Cells
Prostatic Neoplasms--genetics
Sequestosome-1 Protein--genetics
Serine Endopeptidases--genetics
Thiourea--analogs & derivatives