Paricalcitol accelerates BACE1 lysosomal degradation and inhibits calpain-1 dependent neuronal loss in APP/PS1 transgenic mice.

Fan, Yong-Gang

Paricalcitol accelerates BACE1 lysosomal degradation and inhibits calpain-1 dependent neuronal loss in APP/PS1 transgenic mice. [electronic resource] - EBioMedicine Jul 2019 - 393-407 p. digital

Publication Type: Journal Article

2352-3964

10.1016/j.ebiom.2019.07.014 doi


8-Hydroxy-2'-Deoxyguanosine--metabolism
Alzheimer Disease--drug therapy
Amyloid Precursor Protein Secretases--genetics
Amyloid beta-Peptides--genetics
Animals
Aspartic Acid Endopeptidases--genetics
Brain--metabolism
Calpain--genetics
Disease Models, Animal
Ergocalciferols--pharmacology
Gene Expression Regulation--drug effects
Humans
Low Density Lipoprotein Receptor-Related Protein-1--genetics
Lysosomes--drug effects
Mice
Mice, Transgenic
Mitochondria--metabolism
Neurons--drug effects
Oligopeptides--genetics
Presenilin-1--genetics
Proteolysis--drug effects