Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance.

Agudelo, Leandro Z

Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance. [electronic resource] - Nature communications 06 2019 - 2767 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2041-1723

10.1038/s41467-019-10712-0 doi


Adaptation, Physiological
Animals
Aspartate Aminotransferases--metabolism
Aspartic Acid--metabolism
Carbidopa--pharmacology
Cell Respiration--drug effects
Energy Metabolism--drug effects
Fatigue--physiopathology
Glycolysis--physiology
Kynurenine--metabolism
Malates--metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mitochondria--drug effects
Models, Animal
Muscle, Skeletal--metabolism
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha--genetics
Physical Conditioning, Animal--physiology
Protein Isoforms--genetics
Transaminases--antagonists & inhibitors