Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia.

Adelman, Emmalee R

Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia. [electronic resource] - Cancer discovery 08 2019 - 1080-1101 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

2159-8290

10.1158/2159-8290.CD-18-1474 doi


Cell Differentiation--genetics
Cellular Reprogramming--genetics
Cellular Senescence--genetics
Cytosine--metabolism
DNA Methylation
Disease Susceptibility
Enhancer Elements, Genetic
Epigenesis, Genetic
Gene Expression Profiling
Gene Expression Regulation, Leukemic
Hematopoietic Stem Cells--metabolism
Histones--metabolism
Humans
Kruppel-Like Factor 6--genetics
Leukemia--genetics
Promoter Regions, Genetic
Transcription Factors--metabolism