Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone.
Skinner-Adams, Tina S
Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone. [electronic resource] - Communications biology 2019 - 166 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2399-3642
10.1038/s42003-019-0397-3 doi
Animals
Anopheles
Antimalarials--chemistry
Atovaquone--chemistry
Cyclization--drug effects
Dihydroorotate Dehydrogenase
Dose-Response Relationship, Drug
Drug Combinations
Electron Transport Complex III--antagonists & inhibitors
Enzyme Inhibitors--chemistry
Erythrocytes--drug effects
Folic Acid--metabolism
Hep G2 Cells
Humans
Inhibitory Concentration 50
Liver--drug effects
Oxidoreductases Acting on CH-CH Group Donors--metabolism
Plasmodium berghei--drug effects
Plasmodium falciparum--drug effects
Proguanil--analogs & derivatives
Sporozoites--drug effects
Terpenes--metabolism
Triazines--chemistry
Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone. [electronic resource] - Communications biology 2019 - 166 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2399-3642
10.1038/s42003-019-0397-3 doi
Animals
Anopheles
Antimalarials--chemistry
Atovaquone--chemistry
Cyclization--drug effects
Dihydroorotate Dehydrogenase
Dose-Response Relationship, Drug
Drug Combinations
Electron Transport Complex III--antagonists & inhibitors
Enzyme Inhibitors--chemistry
Erythrocytes--drug effects
Folic Acid--metabolism
Hep G2 Cells
Humans
Inhibitory Concentration 50
Liver--drug effects
Oxidoreductases Acting on CH-CH Group Donors--metabolism
Plasmodium berghei--drug effects
Plasmodium falciparum--drug effects
Proguanil--analogs & derivatives
Sporozoites--drug effects
Terpenes--metabolism
Triazines--chemistry