In vitro and computational studies showed that perezone inhibits PARP-1 and induces changes in the redox state of K562 cells.

Hernández-Rodríguez, Maricarmen

In vitro and computational studies showed that perezone inhibits PARP-1 and induces changes in the redox state of K562 cells. [electronic resource] - Archives of biochemistry and biophysics 08 2019 - 225-234 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1096-0384

10.1016/j.abb.2019.05.002 doi


Apoptosis--drug effects
Asteraceae--chemistry
Cell Cycle--drug effects
Cell Proliferation--drug effects
Cell Survival--drug effects
Humans
K562 Cells
Molecular Docking Simulation
Molecular Dynamics Simulation
Oxidation-Reduction--drug effects
Poly (ADP-Ribose) Polymerase-1--antagonists & inhibitors
Poly(ADP-ribose) Polymerase Inhibitors--isolation & purification
Sesquiterpenes--isolation & purification