Depletion of B cells rejuvenates the peripheral B-cell compartment but is insufficient to restore immune competence in aging.

Avivi, Irit

Depletion of B cells rejuvenates the peripheral B-cell compartment but is insufficient to restore immune competence in aging. [electronic resource] - Aging cell 08 2019 - e12959 p. digital

Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

1474-9726

10.1111/acel.12959 doi


Adolescent
Adult
Aged
Aging--immunology
Animals
Antigens, CD20--genetics
Antineoplastic Agents, Immunological--therapeutic use
B-Lymphocytes--immunology
Bone Marrow Cells--immunology
Female
Healthy Volunteers
Humans
Lymphocyte Depletion--methods
Lymphoma, B-Cell--blood
Lymphopoiesis--immunology
Male
Mice
Mice, Inbred BALB C
Mice, Transgenic
Middle Aged
Prospective Studies
Rejuvenation--physiology
Rituximab--therapeutic use
Young Adult