Preoperative anxiety-induced glucocorticoid signaling reduces GABAergic markers in spinal cord and promotes postoperative hyperalgesia by affecting neuronal PAS domain protein 4.

Wu, Hao

Preoperative anxiety-induced glucocorticoid signaling reduces GABAergic markers in spinal cord and promotes postoperative hyperalgesia by affecting neuronal PAS domain protein 4. [electronic resource] - Molecular pain - 1744806919850383 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1744-8069

10.1177/1744806919850383 doi


Animals
Anxiety--complications
Basic Helix-Loop-Helix Transcription Factors--metabolism
Biomarkers--metabolism
Corticosterone--blood
Dependovirus--metabolism
Down-Regulation--drug effects
Glucocorticoids--metabolism
Hyperalgesia--complications
Injections, Spinal
Male
Mifepristone--pharmacology
Neurons--drug effects
Postoperative Care
Preoperative Care
RNA Interference
RNA, Messenger--genetics
Rats, Sprague-Dawley
Signal Transduction--drug effects
Spinal Cord--metabolism
Spironolactone--pharmacology
Stress, Psychological--blood
Up-Regulation--drug effects
gamma-Aminobutyric Acid--metabolism