The CTLA-4 x OX40 bispecific antibody ATOR-1015 induces anti-tumor effects through tumor-directed immune activation.
Kvarnhammar, Anne Månsson
The CTLA-4 x OX40 bispecific antibody ATOR-1015 induces anti-tumor effects through tumor-directed immune activation. [electronic resource] - Journal for immunotherapy of cancer 04 2019 - 103 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2051-1426
10.1186/s40425-019-0570-8 doi
Animals
Antibodies, Bispecific--pharmacology
CHO Cells
CTLA-4 Antigen--antagonists & inhibitors
Cell Line, Tumor--transplantation
Cricetulus
Disease Models, Animal
Drug Screening Assays, Antitumor
Female
HEK293 Cells
Humans
Male
Mice
Mice, Transgenic
Primary Cell Culture
Proof of Concept Study
Receptors, OX40--agonists
T-Lymphocytes, Regulatory--drug effects
Urinary Bladder Neoplasms--drug therapy
The CTLA-4 x OX40 bispecific antibody ATOR-1015 induces anti-tumor effects through tumor-directed immune activation. [electronic resource] - Journal for immunotherapy of cancer 04 2019 - 103 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2051-1426
10.1186/s40425-019-0570-8 doi
Animals
Antibodies, Bispecific--pharmacology
CHO Cells
CTLA-4 Antigen--antagonists & inhibitors
Cell Line, Tumor--transplantation
Cricetulus
Disease Models, Animal
Drug Screening Assays, Antitumor
Female
HEK293 Cells
Humans
Male
Mice
Mice, Transgenic
Primary Cell Culture
Proof of Concept Study
Receptors, OX40--agonists
T-Lymphocytes, Regulatory--drug effects
Urinary Bladder Neoplasms--drug therapy