Translation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase

Begg, Malcolm

Translation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase [electronic resource] - The Journal of pharmacology and experimental therapeutics 06 2019 - 443-453 p. digital

Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

1521-0103

10.1124/jpet.119.257311 doi


Administration, Inhalation
Adult
Animals
Bronchoalveolar Lavage
Eosinophilia--drug therapy
Female
Humans
Indazoles--administration & dosage
Lung--metabolism
Male
Mice
Middle Aged
Permeability
Phosphoinositide-3 Kinase Inhibitors--administration & dosage
Safety
Solubility
Sputum--drug effects
Sulfonamides--administration & dosage
Translational Research, Biomedical