A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma.

Hayes, Tikvah K

A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma. [electronic resource] - Cancer research 05 2019 - 2352-2366 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1538-7445

10.1158/0008-5472.CAN-18-2711 doi


Antineoplastic Agents--pharmacology
Apoptosis
Cell Cycle Checkpoints
Cell Proliferation
Cyclin-Dependent Kinase 4--antagonists & inhibitors
Cyclin-Dependent Kinase 6--antagonists & inhibitors
Drug Resistance, Neoplasm--genetics
GTP Phosphohydrolases--genetics
Humans
MAP Kinase Kinase 1--antagonists & inhibitors
MAP Kinase Kinase 2--antagonists & inhibitors
Melanoma--drug therapy
Membrane Proteins--genetics
Mutation
Phosphorylation
Signal Transduction--drug effects
Tumor Cells, Cultured